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B-NDG knockout mice

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  • Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
  • Coat: Albino
  • Common gamma chain gene (II2rg) interrupted
  • Deficiency in cytokine signaling
  • Deficient in T and B cells
  • High humanization capability
  • Lacks functional receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21
  • Lacks NK cells
  • Severe lymphocyte development impairment
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Brand: Envigo

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