CD-1® Nude Mice

Athymic, T-cell deficient. Used for xenograft tumor research, infectious disease research, lymphocyte stem cell research, and immunology research.

Strain Origin:

In 1979, Charles River introduced the nude gene from Crl:NU-Foxn1nu into CD-1 mice. Through a series of matings and backcrosses, the CD1-Foxn1nu strain was established. These mice are athymic, immunodeficient, and cannot produce T cells.

Vital River has introduced the core group of this strain multiple times from Charles River in 2005, 2017, and 2022.

☑ More nude mouse strains: BALB/c Nude mice, NU/NU mice, nude rats, and SRG rats.

Application Characteristics:

Coat Color: Hairless, albino background

Research Applications: Xenograft tumor research, infectious disease research, lymphocyte stem cell research, immunology research, dermatological research, and endocrine deficiency research: adrenocortical deficiency, thyroid deficiency, and thymic deficiency.

Characteristics:

• CD-1 (ICR) background, carrying the Foxn1nu mutation, leading to thymic aplasia, T-cell deficiency, and cellular immunodeficiency. Also exhibits a limited response to thymus-dependent antigens, resulting in impaired B-cell function.
• Normal macrophage, NK cell, and antigen-presenting cell numbers and function, as well as normal complement activity.
• Normal hair follicle function, but impaired hair development leading to abnormal hair growth. Most hairs cannot penetrate the surface, resulting in a visibly "nude" skin. Note: Some short, curly, and easily broken hairs may be present on the skin surface; this is normal.
• Homozygous pups can be identified at 24 hours of age because they lack whiskers or have poorly developed, curled whiskers.
• Female nude mice cannot effectively lactate or ovulate and are not effective breeders.