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NOD.SCID mice

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  • Autosomal recessive, single nucleotide polymorphism with Prkdc gene on chromosome 16
  • Coat: Albino
  • Development of autoimmune diabetes does not occur due to severe combined immunodeficiency
  • Highly susceptible to opportunistic viral and bacterial infection
  • Natural Killer (NK) cell, macrophage and granulocyte numbers and function are reduced
  • Severe combined immunodeficiency affecting T- and B-lymphocyte development
  • Spontaneous thymic lymphomas
  • As SCID mice age, a variable percentage become 'leaky' from spontaneous development of functional T- and B-lymphocytes
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品牌: Envigo

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